Royal Air Force Typhoon jets have operated alongside French warplanes in a combined operation on an hidden munitions depot in Syrian territory used by the IS group, as stated by the British defence ministry.
The site, pinpointed through intelligence, was believed to be housing weapons and explosive materials, the release indicated, and was situated in mountainous terrain just north of Palmyra in Syria's central region.
"The RAF jets used precision-guided Paveway IV munitions to strike a series of access tunnels down to the depot... early reports suggest the strike was effective," the ministry announced.
There was no sign of any harm to civilians in the attack on Saturday evening and each participating jet returned safely, the MoD added.
The British jets were supported by a Voyager aerial refuelling aircraft.
Daesh - also known as the so-called Islamic State - established jihadist rule over parts of both Syria and Iraq before its territorial defeat in 2019.
"This strike underscores British leadership, and commitment to stand shoulder to shoulder with our allies, to eradicate any resurgence of the terrorist group and their dangerous and violent ideologies in the Middle East," Britain's Defence Chief the Defence Secretary remarked.
British military aircraft have performed patrols over Syria to "forestall any attempted resurgence" of the group following its military defeat at the Baghuz confrontation in the year 2019, the ministry said.
"I must thank all the members of the UK armed forces who took part in this strike for their skill and their bravery," the Defence Secretary added. "They were among numerous British troops deployed over the holidays. This mission, to take out militants who endanger our safety, demonstrates how UK forces are ready to step up, throughout the year, ensuring Britain's security within its borders and strong abroad."
In December, the United States armed forces executed what it called a "massive strike" on Islamic State objectives in the country, following an attack resulted in the deaths of two American soldiers and a civilian linguist in the Palmyra area.
The United Nations reports Daesh still boasts roughly 5-7 thousand fighters in Iraq and Syria.